[HTML][HTML] SOCS-3 is an insulin-induced negative regulator of insulin signaling
B Emanuelli, P Peraldi, C Filloux… - Journal of Biological …, 2000 - ASBMB
The SOCS proteins are induced by several cytokines and are involved in negative feedback
loops. Here we demonstrate that in 3T3-L1 adipocytes, insulin, a hormone whose receptor
does not belong to the cytokine receptor family, induces SOCS-3 expression but not CIS or
SOCS-2. Using transfection of COS-7 cells, we show that insulin induction of SOCS-3 is
enhanced upon Stat5B expression. Moreover, Stat5B from insulin-stimulated cells binds
directly to a Stat element present in the SOCS-3 promoter. Once induced, SOCS-3 inhibits …
loops. Here we demonstrate that in 3T3-L1 adipocytes, insulin, a hormone whose receptor
does not belong to the cytokine receptor family, induces SOCS-3 expression but not CIS or
SOCS-2. Using transfection of COS-7 cells, we show that insulin induction of SOCS-3 is
enhanced upon Stat5B expression. Moreover, Stat5B from insulin-stimulated cells binds
directly to a Stat element present in the SOCS-3 promoter. Once induced, SOCS-3 inhibits …