The mitochondrial permeability transition in neurologic disease

MD Norenberg, KVR Rao - Neurochemistry international, 2007 - Elsevier
Mitochondria, being the principal source of cellular energy, are vital for cell life. Yet,
ironically, they are also major mediators of cell death, either by necrosis or apoptosis. One
means by which these adverse effects occur is through the mitochondrial permeability
transition (mPT) whereby the inner mitochondrial membrane suddenly becomes excessively
permeable to ions and other solutes, resulting in a collapse of the inner membrane potential,
ultimately leading to energy failure and cell necrosis. The mPT may also bring about the …