[HTML][HTML] MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis
N Felli, F Pedini, P Romania, M Biffoni, O Morsilli… - …, 2009 - ncbi.nlm.nih.gov
N Felli, F Pedini, P Romania, M Biffoni, O Morsilli, G Castelli, S Santoro, S Chicarella…
haematologica, 2009•ncbi.nlm.nih.govBackground MicroRNAs are small non-coding RNAs that regulate gene expression through
mRNA degradation or translational inhibition. MicroRNAs are emerging as key regulators of
normal hematopoiesis and hematologic malignancies. Several miRNAs are differentially
expressed during hematopoiesis and their specific expression regulates key functional
proteins involved in hematopoietic lineage differentiation. This study focused on the
functional role of microRNA-223 (miR-223) on erythroid differentiation.
mRNA degradation or translational inhibition. MicroRNAs are emerging as key regulators of
normal hematopoiesis and hematologic malignancies. Several miRNAs are differentially
expressed during hematopoiesis and their specific expression regulates key functional
proteins involved in hematopoietic lineage differentiation. This study focused on the
functional role of microRNA-223 (miR-223) on erythroid differentiation.
Abstract
Background
MicroRNAs are small non-coding RNAs that regulate gene expression through mRNA degradation or translational inhibition. MicroRNAs are emerging as key regulators of normal hematopoiesis and hematologic malignancies. Several miRNAs are differentially expressed during hematopoiesis and their specific expression regulates key functional proteins involved in hematopoietic lineage differentiation. This study focused on the functional role of microRNA-223 (miR-223) on erythroid differentiation.
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