Identification and characterization of macrophage inflammatory protein 2.
SD Wolpe, B Sherry, D Juers… - Proceedings of the …, 1989 - National Acad Sciences
SD Wolpe, B Sherry, D Juers, G Davatelis, RW Yurt, A Cerami
Proceedings of the National Academy of Sciences, 1989•National Acad SciencesIn response to endotoxin, macrophages secrete a protein with a molecular mass of
approximately 6000 Da and with an affinity for heparin. This protein, which we term"
macrophage inflammatory protein 2," is a potent chemotactic agent for human
polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine
causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity
to a family of proteins, the archetype of which is platelet factor 4. Although macrophage …
approximately 6000 Da and with an affinity for heparin. This protein, which we term"
macrophage inflammatory protein 2," is a potent chemotactic agent for human
polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine
causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity
to a family of proteins, the archetype of which is platelet factor 4. Although macrophage …
In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity to a family of proteins, the archetype of which is platelet factor 4. Although macrophage inflammatory protein 2 is a distinct member of the platelet factor 4 family, its sequence is most closely related to that of the gro/KC gene product, which is expressed in transformed or platelet-derived growth factor-treated cells.
National Acad Sciences