Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice
RW Sidwell, JH Huffman, J Gilbert… - Antimicrobial agents …, 1992 - Am Soc Microbiol
RW Sidwell, JH Huffman, J Gilbert, B Moscon, G Pedersen, R Burger, RP Warren
Antimicrobial agents and chemotherapy, 1992•Am Soc MicrobiolPulmonary disease in mice induced by influenza virus was monitored by measurement of
oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse
proportion to the viral inoculum. The known antiviral agent ribavirin inhibited the SaO2
decline, prevented death, lowered lung consolidation, and reduced the level of recoverable
virus. Pulse oximetry is an effective means of monitoring murine influenzal disease and can
be used in the study of potential antiviral drugs.
oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse
proportion to the viral inoculum. The known antiviral agent ribavirin inhibited the SaO2
decline, prevented death, lowered lung consolidation, and reduced the level of recoverable
virus. Pulse oximetry is an effective means of monitoring murine influenzal disease and can
be used in the study of potential antiviral drugs.
Pulmonary disease in mice induced by influenza virus was monitored by measurement of oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse proportion to the viral inoculum. The known antiviral agent ribavirin inhibited the SaO2 decline, prevented death, lowered lung consolidation, and reduced the level of recoverable virus. Pulse oximetry is an effective means of monitoring murine influenzal disease and can be used in the study of potential antiviral drugs.
American Society for Microbiology