[HTML][HTML] The targeted podocyte

AB Fogo - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
The Journal of clinical investigation, 2011Am Soc Clin Investig
The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in
glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and
progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably
decreased or caused proteinuria and sclerosis in human disease and experimental settings.
In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the
mTOR system shed light on the complexity of this pathway in the podocyte.
The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte.
The Journal of Clinical Investigation