A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples
P Roussos, P Katsel, KL Davis, LJ Siever… - Archives of general …, 2012 - jamanetwork.com
Context Schizophrenia is a common, highly heritable, neurodevelopmental mental illness,
characterized by genetic heterogeneity. Objective To identify abnormalities in the
transcriptome organization among older persons with schizophrenia and controls. Design
Weighted gene coexpression network analysis based on microarray transcriptomic profiling.
Setting Research hospital. Patients Postmortem brain tissue samples from 4 different
cerebrocortical regions (the dorsolateral prefrontal cortex, the middle temporal area, the …
characterized by genetic heterogeneity. Objective To identify abnormalities in the
transcriptome organization among older persons with schizophrenia and controls. Design
Weighted gene coexpression network analysis based on microarray transcriptomic profiling.
Setting Research hospital. Patients Postmortem brain tissue samples from 4 different
cerebrocortical regions (the dorsolateral prefrontal cortex, the middle temporal area, the …