Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes …
L Zhang, L Radigan, U Salzer, TW Behrens… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Mutations in the gene coding for transmembrane activator and calcium-
modulating cyclophilin ligand interactor (TACI) have been identified in common variable
immunodeficiency (CVID). Mutations coincided with immunodeficiency in families,
suggesting dominant inheritance. OBJECTIVE: Because most subjects with CVID have no
immunodeficient family members and heterozygous mutations predominate, the role of TACI
mutations in sporadic CVID is unclear. METHODS: TACI was sequenced from the genomic …
modulating cyclophilin ligand interactor (TACI) have been identified in common variable
immunodeficiency (CVID). Mutations coincided with immunodeficiency in families,
suggesting dominant inheritance. OBJECTIVE: Because most subjects with CVID have no
immunodeficient family members and heterozygous mutations predominate, the role of TACI
mutations in sporadic CVID is unclear. METHODS: TACI was sequenced from the genomic …