Much of the focus of neurobiological research into schizophrenia is based on the concept
that disrupted synaptic connectivity underlies the pathology of the disorder. Disruption of
synaptic connectivity is proposed to be a consequence of both disrupted synaptic
transmission in adulthood and abnormalities in the processes controlling synaptic
connectivity during development of the central nervous system. This synaptic hypothesis fits
with neurodevelopmental models of schizophrenia and our understanding of the …