Corticostriatal connectivity and its role in disease

GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Nature Reviews Neuroscience, 2013nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct
classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons.
Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all
levels of functional organization, from cellular signalling mechanisms to circuit topology.
There is also growing evidence for IT/PT imbalance as an aetiological factor in …
Abstract
Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders — autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
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