Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension
T Jacques, N Picard, RL Miller… - Journal of the …, 2013 - journals.lww.com
Inherited and acquired disorders that enhance the activity of transporters mediating renal
tubular Na+ reabsorption are well established causes of hypertension. It is unclear,
however, whether primary activation of an Na+-independent chloride transporter in the
kidney can also play a pathogenic role in this disease. Here, mice overexpressing the
chloride transporter pendrin in intercalated cells of the distal nephron (Tg B1-hPDS mice)
displayed increased renal absorption of chloride. Compared with normal mice, these …
tubular Na+ reabsorption are well established causes of hypertension. It is unclear,
however, whether primary activation of an Na+-independent chloride transporter in the
kidney can also play a pathogenic role in this disease. Here, mice overexpressing the
chloride transporter pendrin in intercalated cells of the distal nephron (Tg B1-hPDS mice)
displayed increased renal absorption of chloride. Compared with normal mice, these …