[HTML][HTML] Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30
E Mironova, J Peti-Peterdi, V Bugaj… - Journal of biological …, 2011 - ASBMB
We tested whether ATP release through Connexin 30 (Cx30) is part of a local purinergic
regulatory system intrinsic to the aldosterone-sensitive distal nephron (ASDN) important for
proper control of sodium excretion; if changes in sodium intake influence ATP release via
Cx30; and if this allows a normal ENaC response to changes in systemic sodium levels. In
addition, we define the consequences of disrupting ATP regulation of ENaC in Cx30−/−
mice. Urinary ATP levels in wild-type mice increase with sodium intake, being lower and less …
regulatory system intrinsic to the aldosterone-sensitive distal nephron (ASDN) important for
proper control of sodium excretion; if changes in sodium intake influence ATP release via
Cx30; and if this allows a normal ENaC response to changes in systemic sodium levels. In
addition, we define the consequences of disrupting ATP regulation of ENaC in Cx30−/−
mice. Urinary ATP levels in wild-type mice increase with sodium intake, being lower and less …