[HTML][HTML] Structure of the active N-terminal domain of Ezrin: conformational and mobility changes identify keystone interactions
WJ Smith, N Nassar, A Bretscher, RA Cerione… - Journal of Biological …, 2003 - ASBMB
Ezrin is a member of the ERM (ezrin, radixin, moesin) family of proteins that cross-link the
actin cytoskeleton to the plasma membrane and also may function in signaling cascades
that regulate the assembly of actin stress fibers. Here, we report a crystal structure for the
free (activated) FERM domain (residues 2–297) of recombinant human ezrin at 2.3 Å
resolution. Structural comparison among the dormant moesin FERM domain structure and
the three known active FERM domain structures (radixin, moesin, and now ezrin) allows the …
actin cytoskeleton to the plasma membrane and also may function in signaling cascades
that regulate the assembly of actin stress fibers. Here, we report a crystal structure for the
free (activated) FERM domain (residues 2–297) of recombinant human ezrin at 2.3 Å
resolution. Structural comparison among the dormant moesin FERM domain structure and
the three known active FERM domain structures (radixin, moesin, and now ezrin) allows the …