The ubiquitin system
A Varshavsky - Trends in biochemical sciences, 1997 - cell.com
A Varshavsky
Trends in biochemical sciences, 1997•cell.comEukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to
a variety of intracellular proteins that bear degradation signals recognized by this system.
The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large
ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes,
including cell differentiation, the cell cycle and responses to stress.
a variety of intracellular proteins that bear degradation signals recognized by this system.
The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large
ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes,
including cell differentiation, the cell cycle and responses to stress.
Abstract
Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
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