[HTML][HTML] PU. 1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in …
W Huang, E Horvath, EA Eklund - Journal of Biological Chemistry, 2007 - ASBMB
Nf1 (neurofibromin 1) is a Ras-GAP protein that regulates cytokine-induced proliferation of
myeloid cells. In previous studies, we found that the interferon consensus sequence-binding
protein (ICSBP; also referred to as interferon regulatory factor 8) activates transcription of the
gene encoding Nf1 (the NF1 gene) in differentiating myeloid cells. We also found that NF1
activation requires cytokine-stimulated phosphorylation of a conserved tyrosine residue in
the interferon regulatory factor (IRF) domain of ICSBP/IRF8. In this study, we found that …
myeloid cells. In previous studies, we found that the interferon consensus sequence-binding
protein (ICSBP; also referred to as interferon regulatory factor 8) activates transcription of the
gene encoding Nf1 (the NF1 gene) in differentiating myeloid cells. We also found that NF1
activation requires cytokine-stimulated phosphorylation of a conserved tyrosine residue in
the interferon regulatory factor (IRF) domain of ICSBP/IRF8. In this study, we found that …