Control of acute myeloid leukemia relapse—dance between KIRs and HLA
JS Miller, BR Blazar - New England Journal of Medicine, 2012 - Mass Medical Soc
JS Miller, BR Blazar
New England Journal of Medicine, 2012•Mass Medical SocThe antileukemic effect of allogeneic hematopoietic stem-cell transplantation (HSCT) is
provided by T cells and natural killer (NK) cells. Although T cells recognize malignant cells
with tumor antigens presented by HLA molecules, NK cells recognize the “loss of self” HLA
induced by transformation, stress, or infection. 1 The net balance of inhibitory and activating
signals determines the NK-specific target-cell response. The gene content of the killer-cell
immunoglobulin-like receptor (KIR) family of inhibitory or activating NK-cell receptors can be …
provided by T cells and natural killer (NK) cells. Although T cells recognize malignant cells
with tumor antigens presented by HLA molecules, NK cells recognize the “loss of self” HLA
induced by transformation, stress, or infection. 1 The net balance of inhibitory and activating
signals determines the NK-specific target-cell response. The gene content of the killer-cell
immunoglobulin-like receptor (KIR) family of inhibitory or activating NK-cell receptors can be …
The antileukemic effect of allogeneic hematopoietic stem-cell transplantation (HSCT) is provided by T cells and natural killer (NK) cells. Although T cells recognize malignant cells with tumor antigens presented by HLA molecules, NK cells recognize the “loss of self” HLA induced by transformation, stress, or infection.1 The net balance of inhibitory and activating signals determines the NK-specific target-cell response. The gene content of the killer-cell immunoglobulin-like receptor (KIR) family of inhibitory or activating NK-cell receptors can be used to define two KIR haplotypes.2 KIR A haplotypes include only one activating KIR gene, KIR2DS4; KIR B haplotypes include a variable . . .
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