Validation of an automated computational method for skeletal muscle fibre morphometry analysis

F Garton, JT Seto, KN North, N Yang - Neuromuscular Disorders, 2010 - Elsevier
Accurate and fast measurement of muscle fibre size and evaluation of fibre type proportions
in large cross-sectional areas remains challenging as existing methods require extensive
manual measurements. In this study, we assessed the fibre morphometry of∼ 1000 fibres in
mouse and human control and diseased muscle cross-sections. We compared fibre size,
percentage fibre proportion and percentage fibre surface area results obtained by an
automated method using MetaMorph® with those obtained manually using Image Pro. Data …