[HTML][HTML] Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins
N Frey, EN Olson - Journal of Biological Chemistry, 2002 - ASBMB
The Z-disc is a highly specialized multiprotein complex of striated muscles that serves as the
interface of the sarcomere and the cytoskeleton. In addition to its role in muscle contraction,
its juxtaposition to the plasma membrane suggests additional functions of the Z-disc in
sensing and transmitting external and internal signals. Recently, we described two novel
striated muscle-specific proteins, calsarcin-1 and calsarcin-2, that bind α-actinin on the Z-
disc and serve as intracellular binding proteins for calcineurin, a calcium/calmodulin …
interface of the sarcomere and the cytoskeleton. In addition to its role in muscle contraction,
its juxtaposition to the plasma membrane suggests additional functions of the Z-disc in
sensing and transmitting external and internal signals. Recently, we described two novel
striated muscle-specific proteins, calsarcin-1 and calsarcin-2, that bind α-actinin on the Z-
disc and serve as intracellular binding proteins for calcineurin, a calcium/calmodulin …