The p21activated kinases (PAKs) are one of the first direct kinase targets of Ras-related
small GTPases to be discovered and have emerged as central players in growth factor
signaling networks that regulate morphogenetic processes. In some situations, PAKs control
cell proliferation, but their wider role involves establishing cell polarity and promoting
cellular plasticity via changes in the actin cytoskeleton. PAKs have been shown to impact on
three important areas of human health, namely, cancer, brain function, and virus infection …