KLF6 is one transcription factor involved in regulating acid ceramidase gene expression
Acid ceramidase (AC; EC 3.5. 1.23) activity is required to hydrolyze ceramide into
sphingosine. An inherited deficiency of this enzymatic activity leads to the lipid storage
disorder, Farber Lipogranulomatosis. Aberrant AC activity also has been demonstrated in
several human cancers. We have characterized a 1931-bp putative promoter region of the
murine AC gene by Luciferase reporter assays, electrophoretic mobility shift assays, and
mutational analysis. A 143-bp sequence essential for AC promoter activity was found, and …
sphingosine. An inherited deficiency of this enzymatic activity leads to the lipid storage
disorder, Farber Lipogranulomatosis. Aberrant AC activity also has been demonstrated in
several human cancers. We have characterized a 1931-bp putative promoter region of the
murine AC gene by Luciferase reporter assays, electrophoretic mobility shift assays, and
mutational analysis. A 143-bp sequence essential for AC promoter activity was found, and …