Interdiction of sphingolipid metabolism to improve standard cancer therapies
TH Beckham, JC Cheng, ST Marrison, JS Norris… - Advances in cancer …, 2013 - Elsevier
Non-surgical therapies for human malignancies must negotiate complex cell signaling
pathways to impede cancer cell growth, ideally promoting death of cancer cells while
sparing healthy tissue. For most of the past half century, medical approaches for treating
cancer have relied primarily on cytotoxic chemotherapeutics that interfere with DNA
replication and cell division, susceptibilities of rapidly dividing cancer cells. As a
consequence, these therapies exert considerable cell stress, promoting the generation of …
pathways to impede cancer cell growth, ideally promoting death of cancer cells while
sparing healthy tissue. For most of the past half century, medical approaches for treating
cancer have relied primarily on cytotoxic chemotherapeutics that interfere with DNA
replication and cell division, susceptibilities of rapidly dividing cancer cells. As a
consequence, these therapies exert considerable cell stress, promoting the generation of …