Autophagy is a tightly regulated, programmed mechanism to eliminate damaged organelles
and proteins from a cell to maintain homeostasis. Cisplatin, a chemotherapeutic agent,
accumulates in the proximal tubules of the kidney and causes dose-dependent
nephrotoxicity, which may involve autophagy. In the kidney, cisplatin induces the protective
antioxidant heme oxygenase-1 (HO-1). In this study, we examined the relationship between
autophagy and HO-1 during cisplatin-mediated acute kidney injury (AKI). In wild-type …