[PDF][PDF] Plgf −/−eNos−/− mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia
B Gigante, G Morlino, MT Gentile, MG Persico… - The FASEB …, 2006 - academia.edu
B Gigante, G Morlino, MT Gentile, MG Persico, S De Falco, B Gigante, G Morlino, MT Gentile…
The FASEB journal, 2006•academia.eduPlacental growth factor (PlGF) and endothelial nitric oxide synthase (eNOS) play a pivotal
role in pathological angiogenesis. PlGF acts in synergism with the vascular endothelial
growth factor (VEGF), whereas eNOS is one of the downstream targets of VEGF. To
investigate the existence of a functional interaction between PlGF and eNOS, we have 1)
generated a congenic line of knockout mice carrying both null mutations and 2) analyzed the
phenotype of this new experimental animal model following surgically induced hind limb …
role in pathological angiogenesis. PlGF acts in synergism with the vascular endothelial
growth factor (VEGF), whereas eNOS is one of the downstream targets of VEGF. To
investigate the existence of a functional interaction between PlGF and eNOS, we have 1)
generated a congenic line of knockout mice carrying both null mutations and 2) analyzed the
phenotype of this new experimental animal model following surgically induced hind limb …
Placental growth factor (PlGF) and endothelial nitric oxide synthase (eNOS) play a pivotal role in pathological angiogenesis. PlGF acts in synergism with the vascular endothelial growth factor (VEGF), whereas eNOS is one of the downstream targets of VEGF. To investigate the existence of a functional interaction between PlGF and eNOS, we have 1) generated a congenic line of knockout mice carrying both null mutations and 2) analyzed the phenotype of this new experimental animal model following surgically induced hind limb ischemia.
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