[HTML][HTML] Loss of p53 compensates for αV-integrin function in retinal neovascularization
S Strömblad, A Fotedar, H Brickner… - Journal of Biological …, 2002 - ASBMB
α v-Integrin antagonists block neovascularization in various species, whereas 20% of α v-
integrin null mice are born with many normal looking blood vessels. Given that blockade of α
v-integrins during angiogenesis induces p53 activity, we utilized p53 null mice to elucidate
whether loss of p53 can compensate for α v-integrin function in neovascularization of the
retina. Murine retinal vascularization was inhibited by systemic administration of an α v-
integrin antagonist. In contrast, mice lacking p53 were refractory to this treatment, indicating …
integrin null mice are born with many normal looking blood vessels. Given that blockade of α
v-integrins during angiogenesis induces p53 activity, we utilized p53 null mice to elucidate
whether loss of p53 can compensate for α v-integrin function in neovascularization of the
retina. Murine retinal vascularization was inhibited by systemic administration of an α v-
integrin antagonist. In contrast, mice lacking p53 were refractory to this treatment, indicating …