Immature renal dendritic cells recruit regulatory CXCR6+ invariant natural killer T cells to attenuate crescentic GN
JH Riedel, HJ Paust, JE Turner, AP Tittel… - Journal of the …, 2012 - journals.lww.com
Immature renal dendritic cells (DCs) are protective early in murine crescentic GN, but the
mechanisms underlying this protection are unknown. Here, depletion of DCs reduced the
recruitment of invariant natural killer T (iNKT) cells, which attenuate GN, into the kidney in
the early stage of experimental crescentic GN. More than 90% of renal iNKT cells expressed
the chemokine receptor CXCR6, and renal DCs produced high amounts of the cognate
ligand CXCL16 early after induction of nephritis, suggesting that renal DC-derived CXCL16 …
mechanisms underlying this protection are unknown. Here, depletion of DCs reduced the
recruitment of invariant natural killer T (iNKT) cells, which attenuate GN, into the kidney in
the early stage of experimental crescentic GN. More than 90% of renal iNKT cells expressed
the chemokine receptor CXCR6, and renal DCs produced high amounts of the cognate
ligand CXCL16 early after induction of nephritis, suggesting that renal DC-derived CXCL16 …