Transcriptional signaling by double-stranded RNA: role of TLR3
GC Sen, SN Sarkar - Cytokine & growth factor reviews, 2005 - Elsevier
Mammalian Toll-like receptors recognize components of invading microbes and trigger the
first line of innate immune response that is mediated by transcriptional induction of a large
number of cellular genes. Toll-like receptor 3 (TLR3) is thought to be a major mediator of
cellular response to viral infection, because it responds to double-stranded (ds) RNA, a
common by-product of viral replication. This article is focused on the nature of the signaling
pathways activated by TLR3 and dsRNA. The genes induced by TLR3 activation include …
first line of innate immune response that is mediated by transcriptional induction of a large
number of cellular genes. Toll-like receptor 3 (TLR3) is thought to be a major mediator of
cellular response to viral infection, because it responds to double-stranded (ds) RNA, a
common by-product of viral replication. This article is focused on the nature of the signaling
pathways activated by TLR3 and dsRNA. The genes induced by TLR3 activation include …