[HTML][HTML] Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
L Adam, R Vadlamudi, SB Kondapaka… - Journal of Biological …, 1998 - ASBMB
The mechanisms through which heregulin (HRG) regulates the activities of breast cancer
cells are currently unknown. We demonstrate that HRG stimulation of noninvasive breast
cancer cells enhanced the conversion of globular to filamentous actin and the formation of
membrane ruffles, stress fibers, filopodia, and lamellipodia and accompanied by increased
cell migration. In addition, HRG triggered a rapid stimulation of p21-activated kinase1
(PAK1) activity and its redistribution into the leading edges of motile cells. The HRG-induced …
cells are currently unknown. We demonstrate that HRG stimulation of noninvasive breast
cancer cells enhanced the conversion of globular to filamentous actin and the formation of
membrane ruffles, stress fibers, filopodia, and lamellipodia and accompanied by increased
cell migration. In addition, HRG triggered a rapid stimulation of p21-activated kinase1
(PAK1) activity and its redistribution into the leading edges of motile cells. The HRG-induced …