[HTML][HTML] Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

V Munugalavadla, EC Sims, RJ Chan, SD Lenz… - Experimental …, 2008 - Elsevier
OBJECTIVE: Oncogenic activation loop mutations of KIT are observed in acute myeloid
leukemia (AML) and in myeloproliferative disorders (MPD); however, the signaling pathways
that contribute to transformation via these mutations in vivo are not known. Previous studies
have demonstrated hyperactivation of p85α regulatory subunit of class IA
phosphatidylinositol-3-kinase (PI3K) in cell lines expressing the activation loop mutant of KIT
(KITD816V [human] and KITD814V [murine]). Although p85α is hyperphosphorylated and …