GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus
LJ McCulloch, M van de Bunt, M Braun… - Molecular genetics and …, 2011 - Elsevier
SLC2A2 encoding glucose transporter− 2 (GLUT2) acts as the primary glucose transporter
and sensor in rodent pancreatic islets and is widely assumed to play a similar role in
humans. In healthy adults SLC2A2 variants are associated with elevated fasting plasma
glucose (fpg) concentrations but physiological characterisation does not support a defect in
pancreatic beta-cell function. Interspecies differences can create barriers for the follow up of
disease association signals. We hypothesised that GLUT2 is not the principal glucose …
and sensor in rodent pancreatic islets and is widely assumed to play a similar role in
humans. In healthy adults SLC2A2 variants are associated with elevated fasting plasma
glucose (fpg) concentrations but physiological characterisation does not support a defect in
pancreatic beta-cell function. Interspecies differences can create barriers for the follow up of
disease association signals. We hypothesised that GLUT2 is not the principal glucose …