Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies
RHJ Van der Linden, LGJ Frenken, B De Geus… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Antigen specific llama VHH antibody fragments were compared to antigen specific mouse
monoclonal antibodies with respect to specificity, affinity and stability. The llama VHH
antibody fragments and the mouse monoclonal antibodies investigated were shown to be
highly specific for the protein antigen hCG or the hapten antigen RR-6. The affinity of the
interaction between monovalent llama VHH antibody fragments and their antigen is close to
the nanomolar range, similar to the bivalent mouse monoclonal antibodies studied. Llama …
monoclonal antibodies with respect to specificity, affinity and stability. The llama VHH
antibody fragments and the mouse monoclonal antibodies investigated were shown to be
highly specific for the protein antigen hCG or the hapten antigen RR-6. The affinity of the
interaction between monovalent llama VHH antibody fragments and their antigen is close to
the nanomolar range, similar to the bivalent mouse monoclonal antibodies studied. Llama …