[HTML][HTML] Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

NC Patel, PM Hertel, MK Estes… - … England Journal of …, 2010 - Mass Medical Soc
NC Patel, PM Hertel, MK Estes, M De La Morena, AM Petru, LM Noroski, PA Revell…
New England Journal of Medicine, 2010Mass Medical Soc
Live pentavalent human–bovine reassortant rotavirus vaccine is recommended in the United
States for routine immunization of infants. We describe three infants, two with failure to thrive,
who had dehydration and diarrhea within 1 month after their first or second rotavirus
immunization and subsequently received a diagnosis of severe combined
immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase–polymerase-
chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene …
Live pentavalent human–bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.
The New England Journal Of Medicine