[HTML][HTML] Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression
Y Liu, S Sinha, OG McDonald, Y Shang… - Journal of Biological …, 2005 - ASBMB
Platelet-derived growth factor BB (PDGF-BB) has been shown to be an extremely potent
negative regulator of smooth muscle cell (SMC) differentiation. Moreover, previous studies
have demonstrated that the Kruppel-like transcription factor (KLF) 4 potently represses the
expression of multiple SMC genes. However, the mechanisms whereby KLF4 suppresses
SMC gene expression are not known, nor is it clear whether KLF4 contributes to PDGF-BB-
induced down-regulation of SMC genes. The goals of the present studies were to determine …
negative regulator of smooth muscle cell (SMC) differentiation. Moreover, previous studies
have demonstrated that the Kruppel-like transcription factor (KLF) 4 potently represses the
expression of multiple SMC genes. However, the mechanisms whereby KLF4 suppresses
SMC gene expression are not known, nor is it clear whether KLF4 contributes to PDGF-BB-
induced down-regulation of SMC genes. The goals of the present studies were to determine …