Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors
JP Schulke, GM Wochnik, I Lang-Rollin, NC Gassen… - PloS one, 2010 - go.gale.com
JP Schulke, GM Wochnik, I Lang-Rollin, NC Gassen, RT Knapp, B Berning, A Yassouridis…
PloS one, 2010•go.gale.comBackground Tetratricopeptide repeat (TPR) motif containing co-chaperones of the
chaperone Hsp90 are considered control modules that govern activity and specificity of this
central folding platform. Steroid receptors are paradigm clients of Hsp90. The influence of
some TPR proteins on selected receptors has been described, but a comprehensive
analysis of the effects of TPR proteins on all steroid receptors has not been accomplished
yet.
chaperone Hsp90 are considered control modules that govern activity and specificity of this
central folding platform. Steroid receptors are paradigm clients of Hsp90. The influence of
some TPR proteins on selected receptors has been described, but a comprehensive
analysis of the effects of TPR proteins on all steroid receptors has not been accomplished
yet.
Abstract
Background
Tetratricopeptide repeat (TPR) motif containing co-chaperones of the chaperone Hsp90 are considered control modules that govern activity and specificity of this central folding platform. Steroid receptors are paradigm clients of Hsp90. The influence of some TPR proteins on selected receptors has been described, but a comprehensive analysis of the effects of TPR proteins on all steroid receptors has not been accomplished yet.
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