Induction of tumor immunity following allogeneic stem cell transplantation
CJ Wu, J Ritz - Advances in immunology, 2006 - Elsevier
The curative potential of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) for
many hematologic malignancies derives in large part from reconstitution of normal donor
immunity and the development of a potent graft‐versus‐leukemia (GVL) immune response
capable of rejecting tumor cell in vivo. Elucidation of the mechanisms of GVL by studies of
animal models and analysis of clinical data has yielded important insights into how clinically
effective tumor immunity is generated following allo‐HSCT. These studies have identified …
many hematologic malignancies derives in large part from reconstitution of normal donor
immunity and the development of a potent graft‐versus‐leukemia (GVL) immune response
capable of rejecting tumor cell in vivo. Elucidation of the mechanisms of GVL by studies of
animal models and analysis of clinical data has yielded important insights into how clinically
effective tumor immunity is generated following allo‐HSCT. These studies have identified …