Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn
Primary afferent A-fiber stimulation normally evokes fast mono-or polysynaptic EPSCs of
short duration. However, in the presence of the GABAA receptor antagonist bicuculline,
repetitive, long lasting, polysynaptic EPSCs can be observed following the initial, fast
response. A-fiber-induced ERK activation is also facilitated in the presence of bicuculline.
The frequency of miniature EPSCs and the amplitude of the monosynaptic A-fiber-evoked
EPSCs are not affected by bicuculline or the GABAA receptor agonist muscimol, suggesting …
short duration. However, in the presence of the GABAA receptor antagonist bicuculline,
repetitive, long lasting, polysynaptic EPSCs can be observed following the initial, fast
response. A-fiber-induced ERK activation is also facilitated in the presence of bicuculline.
The frequency of miniature EPSCs and the amplitude of the monosynaptic A-fiber-evoked
EPSCs are not affected by bicuculline or the GABAA receptor agonist muscimol, suggesting …