[HTML][HTML] A bipartite autoinhibitory region within the B-domain suppresses function in factor V
MHA Bos, RM Camire - Journal of Biological Chemistry, 2012 - ASBMB
Background: Factor V is an inactive procofactor. Removal of its B-domain drives activation
through an undefined mechanism. Results: Basic and acidic regions within the B-domain
impair factor Xa binding and cofactor function. Conclusion: Autoinhibitory B-domain
segments maintain the procofactor state and their disruption activates FV. Significance: The
study provides insights into how FV activation unfolds and defines an unexpected sequence-
specific function of the B-domain.
through an undefined mechanism. Results: Basic and acidic regions within the B-domain
impair factor Xa binding and cofactor function. Conclusion: Autoinhibitory B-domain
segments maintain the procofactor state and their disruption activates FV. Significance: The
study provides insights into how FV activation unfolds and defines an unexpected sequence-
specific function of the B-domain.