Activation of precursor proteins by specific and limited proteolysis is a hallmark of the
hemostatic process. The homologous coagulation factors (F) V and FVIII circulate in an
inactive, quiescent state in blood. In this so‐called procofactor state, these proteins have
little, if any procoagulant activity and do not participate to any significant degree in their
respective macromolecular enzymatic complexes. Thrombin is considered a key
physiological activator, cleaving select peptide bonds in FV and FVIII which ultimately leads …