[HTML][HTML] Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor
WR Gould, P Simioni, JR Silveira, D Tormene… - Journal of Thrombosis …, 2005 - Elsevier
Summary Factor Va (FVa), derived from plasma or released from stimulated platelets, is the
essential cofactor in thrombin production catalyzed by the prothrombinase complex. Plasma-
derived factor V (FV) is synthesized in the liver. The source (s) of the platelet-derived
cofactor remains in question. We identified a patient homozygous for the FV Leiden
mutation, who received a liver transplant from a homozygous wild-type FV donor. Eighteen
days post-transplant, phenotypic analysis of the patient's platelet-derived FV indicated that …
essential cofactor in thrombin production catalyzed by the prothrombinase complex. Plasma-
derived factor V (FV) is synthesized in the liver. The source (s) of the platelet-derived
cofactor remains in question. We identified a patient homozygous for the FV Leiden
mutation, who received a liver transplant from a homozygous wild-type FV donor. Eighteen
days post-transplant, phenotypic analysis of the patient's platelet-derived FV indicated that …