Caspase 3 and 8 deficiency in human neuroblastoma
A Iolascon, A Borriello, L Giordani, V Cucciolla… - Cancer genetics and …, 2003 - Elsevier
An altered apoptotic response represents a pivotal feature of cancer and is involved in
cancerogenesis and resistance to chemotherapy. So far, however, only a few studies have
been devoted to survey caspase content in malignant cell lines and primary tumor
specimens. In this report, we investigated the expression of two pivotal caspases, 3 and 8, in
63 neuroblastoma specimens by three complementary techniques (ie, reverse transcriptase
polymerase chain reaction, immunoblotting, and immunohistochemistry). We confirmed the …
cancerogenesis and resistance to chemotherapy. So far, however, only a few studies have
been devoted to survey caspase content in malignant cell lines and primary tumor
specimens. In this report, we investigated the expression of two pivotal caspases, 3 and 8, in
63 neuroblastoma specimens by three complementary techniques (ie, reverse transcriptase
polymerase chain reaction, immunoblotting, and immunohistochemistry). We confirmed the …