[HTML][HTML] Targeting XIAP for the treatment of malignancy

AD Schimmer, S Dalili, RA Batey, SJ Riedl - Cell Death & Differentiation, 2006 - nature.com
Cell Death & Differentiation, 2006nature.com
X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis
proteins family of caspase inhibitors that selectively binds and inhibits caspases-3,-7 and-9,
but not caspase-8. As such, XIAP blocks a substantial portion of the apoptosis pathway and
is an attractive target for novel therapeutic agents for the treatment of malignancy. Antisense
oligonucleotides directed against XIAP are effective in vitro and are currently being
evaluated in clinical trials. Small molecule XIAP inhibitors that target the baculovirus IAP …
Abstract
X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family of caspase inhibitors that selectively binds and inhibits caspases-3,-7 and-9, but not caspase-8. As such, XIAP blocks a substantial portion of the apoptosis pathway and is an attractive target for novel therapeutic agents for the treatment of malignancy. Antisense oligonucleotides directed against XIAP are effective in vitro and are currently being evaluated in clinical trials. Small molecule XIAP inhibitors that target the baculovirus IAP repeat (BIR) 2 or BIR 3 domain are in preclinical development and are advancing toward the clinic. This review will discuss the progress being made in developing antisense and small-molecule XIAP inhibitors.
nature.com