[HTML][HTML] Human caspase-7 activity and regulation by its N-terminal peptide
JB Denault, GS Salvesen - Journal of Biological Chemistry, 2003 - ASBMB
Central to the execution phase of apoptosis are the two closely related caspase-3 and-7.
They share common substrate specificity and structure, but differ completely in the sequence
of their respective N-terminal regions including their N-peptides, a 23–28 residue segment
that are removed during zymogen activation. We show that the N-peptide of caspase-7 plays
no role in the fundamental activation or properties of the active protease in vitro. However,
the N-peptide modifies the properties of caspase-7 in vivo. In ectopic expression …
They share common substrate specificity and structure, but differ completely in the sequence
of their respective N-terminal regions including their N-peptides, a 23–28 residue segment
that are removed during zymogen activation. We show that the N-peptide of caspase-7 plays
no role in the fundamental activation or properties of the active protease in vitro. However,
the N-peptide modifies the properties of caspase-7 in vivo. In ectopic expression …