A mammalian scaffold complex that selectively mediates MAP kinase activation
AJ Whitmarsh, J Cavanagh, C Tournier, J Yasuda… - Science, 1998 - science.org
The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is
activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was
identified that interacts with multiple components of the JNK signaling pathway, including the
mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7,
and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the
MLK signaling pathway. These data establish that a mammalian scaffold protein can …
activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was
identified that interacts with multiple components of the JNK signaling pathway, including the
mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7,
and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the
MLK signaling pathway. These data establish that a mammalian scaffold protein can …
The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.
AAAS