Mechanisms of disease: vitamin D and inflammatory bowel disease
WC Lim, SB Hanauer, YC Li - Nature clinical practice Gastroenterology …, 2005 - nature.com
WC Lim, SB Hanauer, YC Li
Nature clinical practice Gastroenterology & hepatology, 2005•nature.comAbstract Until recently, 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3)—the active form of
vitamin D—was thought to function primarily as a regulator of calcium and phosphate
metabolism. More diverse functionality was indicated by the discovery of the vitamin D
receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of
the vitamin D receptor in monocytes and activated T cells has sparked interest in the
immunomodulatory properties of vitamin D. Here, we review the role of vitamin D in …
vitamin D—was thought to function primarily as a regulator of calcium and phosphate
metabolism. More diverse functionality was indicated by the discovery of the vitamin D
receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of
the vitamin D receptor in monocytes and activated T cells has sparked interest in the
immunomodulatory properties of vitamin D. Here, we review the role of vitamin D in …
Abstract
Until recently, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)—the active form of vitamin D—was thought to function primarily as a regulator of calcium and phosphate metabolism. More diverse functionality was indicated by the discovery of the vitamin D receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of the vitamin D receptor in monocytes and activated T cells has sparked interest in the immunomodulatory properties of vitamin D. Here, we review the role of vitamin D in regulation of the immune system, and evidence for its involvement in the pathogenesis of inflammatory bowel disease.
nature.com