[HTML][HTML] The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells
W Huang, C Zhu, H Wang, E Horvath… - Journal of biological …, 2008 - ASBMB
The interferon consensus sequence-binding protein (ICSBP/IRF8) is an interferon regulatory
factor that is expressed in myeloid and B-cells. ICSBP-deficient mice develop a
myeloproliferative disorder characterized by cytokine hypersensitivity and apoptosis
resistance. To identify ICSBP target genes involved in these effects, we screened a CpG
island microarray with chromatin that co-immunoprecipitated with ICSBP from myeloid cells.
Using this technique, we identified PTPN13 as an ICSBP target gene. PTPN13 encodes Fas …
factor that is expressed in myeloid and B-cells. ICSBP-deficient mice develop a
myeloproliferative disorder characterized by cytokine hypersensitivity and apoptosis
resistance. To identify ICSBP target genes involved in these effects, we screened a CpG
island microarray with chromatin that co-immunoprecipitated with ICSBP from myeloid cells.
Using this technique, we identified PTPN13 as an ICSBP target gene. PTPN13 encodes Fas …