Retinoids are important physiological agents that regulate epithelial cell differentiation and
proliferation. The importance of these agents in regulating growth, development, and
differentiation has led to a search for new retinoid agonists and antagonists. In the present
manuscript we show that AGN193109, a retinoid analog, is an efficient antagonist of retinoid
action in human cervical epithelial cells. Treatment of ECE16-1 cells with natural or synthetic
retinoids reduces cytokeratin K5, K6, K14, K16, and K17 levels, increases cytokeratin K7 …