[HTML][HTML] Retinoic acid and lipopolysaccharide act synergistically to increase prostanoid concentrations in rats in vivo
Y Devaux, C Seguin, S Grosjean, N de Talance… - The Journal of …, 2001 - Elsevier
Vitamin A and its active metabolite retinoic acid (RA) modulate host-pathogen interactions
by interfering with the host immune and inflammatory response including prostaglandin (PG)
biosynthesis. The effects of RA on phospholipase A 2 (PLA 2) and cyclooxygenase (COX)
isoforms in vitro are controversial, and few in vivo studies exist. We investigated the in vivo
effects of RA on PG biosynthesis in the presence or absence of lipopolysaccharide (LPS) in
rats. RA alone [10 mg/(kg· d) for 5 d] increased plasma and liver PG concentrations by …
by interfering with the host immune and inflammatory response including prostaglandin (PG)
biosynthesis. The effects of RA on phospholipase A 2 (PLA 2) and cyclooxygenase (COX)
isoforms in vitro are controversial, and few in vivo studies exist. We investigated the in vivo
effects of RA on PG biosynthesis in the presence or absence of lipopolysaccharide (LPS) in
rats. RA alone [10 mg/(kg· d) for 5 d] increased plasma and liver PG concentrations by …