Lack of involvement of retinoic acid receptor α in retinoid-induced skin irritation in hairless mice

AM Standeven, M Teng, RAS Chandraratna - Toxicology letters, 1997 - Elsevier
It has been proposed that RARγ, the major retinoic acid receptor (RAR) subtype in skin,
mediates retinoid-induced skin irritation. However, RARα is also found in skin, and its role in
retinoid-induced skin irritation has not been tested. In this study, RAR subtype-specific
agonists and antagonists were used to test the possible contribution of RARα to retinoid-
induced skin irritation. Female hairless mice were treated topically on the dorsal skin for 5
days with various retinoids over a 2-log dose range, and cutaneous toxicity was scored by …