Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1)
T Durmus, RJ LeClair, KS Park, A Terzic, JK Yoon… - Gene Expression …, 2006 - Elsevier
We recently identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene
induced in adventitial fibroblasts after arterial injury. Cthrc1 is a 30kDa secreted protein that
has the ability to inhibit collagen matrix synthesis. Cthrc1 is also glycosylated and retains a
signal sequence consistent with the presence of Cthrc1 in the extracellular space. In injured
arteries and skin wounds, we have found Cthrc1 expression to be associated with
myofibroblasts and sites of collagen matrix deposition. Furthermore, we demonstrated that …
induced in adventitial fibroblasts after arterial injury. Cthrc1 is a 30kDa secreted protein that
has the ability to inhibit collagen matrix synthesis. Cthrc1 is also glycosylated and retains a
signal sequence consistent with the presence of Cthrc1 in the extracellular space. In injured
arteries and skin wounds, we have found Cthrc1 expression to be associated with
myofibroblasts and sites of collagen matrix deposition. Furthermore, we demonstrated that …