The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor β signaling

R LeClair, V Lindner - Trends in cardiovascular medicine, 2007 - Elsevier
Collagen triple helix repeat containing protein 1 (Cthrc1) is a gene product with novel
biochemical activities, and its ability to reduce collagen deposition by inhibition of Smad2/3
activation could have major clinical applications in the fields of vascular disease, repair, and
fibrosis. Currently available data indicate that Cthrc1 expression in vascular cells regulates
transforming growth factor β responsiveness, thereby impacting transforming growth factor β
target genes, including collagens; and regulation or activation of Cthrc1 is strictly controlled …