[HTML][HTML] Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation
R Zhang, ML Brennan, Z Shen, JC MacPherson… - Journal of Biological …, 2002 - ASBMB
Initiation of lipid peroxidation and the formation of bioactive eicosanoids are pivotal
processes in inflammation and atherosclerosis. Currently, lipoxygenases, cyclooxygenases,
and cytochrome P450 monooxygenases are considered the primary enzymatic participants
in these events. Myeloperoxidase (MPO), a heme protein secreted by activated leukocytes,
generates reactive intermediates that promote lipid peroxidation in vitro. For example, MPO
catalyzes oxidation of tyrosine and nitrite to form tyrosyl radical and nitrogen dioxide (⋅ NO …
processes in inflammation and atherosclerosis. Currently, lipoxygenases, cyclooxygenases,
and cytochrome P450 monooxygenases are considered the primary enzymatic participants
in these events. Myeloperoxidase (MPO), a heme protein secreted by activated leukocytes,
generates reactive intermediates that promote lipid peroxidation in vitro. For example, MPO
catalyzes oxidation of tyrosine and nitrite to form tyrosyl radical and nitrogen dioxide (⋅ NO …